The brain as a chemical machine – Nicotinic receptors and neuronal communication – Jean-Pierre Changeux , Stuart Edelstein

Télécharger The brain as a chemical marionnette – Nicotinic receptors and neuronal adresse par l’artisan Pantalon-Calculs Changeux , Stuart Edelstein gratuit

The brain as a chemical machine - Nicotinic receptors and neuronal communication-Jean-Pierre Changeux , Stuart Edelstein

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  • Titre: The brain as a chemical marionnette – Nicotinic receptors and neuronal adresse
  • Auteur: Pantalon-Calculs Changeux , Stuart Edelstein
  • Éditeur: Odile Jacob
  • Date: 06/19/12
  • Nombre de pages: 581
  • Langue: Tricolore
  • EAN: 9782738179470
  • ISBN: 978-2-7381-7947-0

Ici vous pouvez télécharger le livre The brain as a chemical marionnette – Nicotinic receptors and neuronal adresse de l’artisan Pantalon-Calculs Changeux , Stuart Edelstein en format PDF et EPUB. Il a été élaboré par la maison d’publication Odile Jacob et a des pages Nombre caché. La date de publication est 06/19/12. Partout ailleurs où vous devez payer, ici, c’est gratuit.

Résumé

The purpose of this book is to give a clear and straightforward account of the remarkable properties of the nicotinic receptor for acetylcholine, a tunique protein involved in chemical transduction in the nervous system that is also the target of a widely used drug, pétun. This molecule also happens to be the first pharmacological receptor and ion channel ever to have been identified. Pantalon-Calculs Changeux has played a leading role with Stuart J. Edelstein in the reportage of nicotinic acetylcholine receptors and allosteric proteins. The aim of this book is not only to review the most recent experimental and theoretical breakthroughs in the study of the nicotinic receptor, but also to give the reader a sense of the intellectual excitement and adventure that accompanied the various stages of discovery. The story of the receptor for acetylcholine provides a jaloux désir on the development of a branch of instruction at the crossroads of fournaise premier domains: biochemistry, neurophysiology, pharmacology, and the behavioral sciences. An understanding of nicotinic receptors can help patients suffering from a range of neurological and psychiatric discorders, among them Alzheimer’s and Parkinson’s diseases, Tourette’s syndrome, nocturnal frontal lobe epilepsies, and possibly schizophrenic syndromes and autism as well – to say nothing of addiction to pétun itself. For forty years now the nicotinic receptor has served as an outstanding model of incorporation transducers and pharmacological receptors. This richly illustrated cubage furnishes an exceptional opportunity for scientists and students to follow the circonvolution of a premier advance in our understanding of the molecular basis of brain functions.”The nicotinic acetylcholine receptor has served for many decades as the essence for neurotransmitter receptors. Acetylcholine was the first neurotransmitter shown to be involved in the emploi of the mammalian brain and its nicotinic receptor the first receptor to be characterized. Pantalon-Calculs Changeux is the indisputable pioneer in this field. This cubage summarizes with great lucidity the history of a highly notable topic in neuroscience.” Paul Greengard, Nobel laureate in Medecine – The Rockefeller University”From the molecule to thought itself – an extraordinary journey! Changeux and Edelstein are uniquely qualified to relate this utterly fascinating story, whose philosophical implications are no less notable than the scientific research underlying them.” Pantalon-Intact Lehn, Nobel laureate in Chemistry – ISIS-Pension Paillette Officiant, Strasbourg”The human brain is as much a chemical as an electrical network. Its intricacy and artificialité set it apart from any known technical device. The groundbreaking papers by Monod, Jacob, Wyman, and Changeux in the 1960s on chemical regulation and control were eye-opening for all us who were doing experimental research in ths field, and they have turned out to be capital for understanding biological evolution and learning in a broad sense. Since then Changeux and Edelstein have achieved planétaire fame for their work on nicotinic acetylcholine receptors, amply documented in this masterful account.” Manfred Eigen, Nobel laureate in Chemistry – Max Planck Institute for Biophysical Chemistry, Göttingen”One hesitates to call this book a monograph, for despite its comprehensive treatment of a complex subject it is not meant solely for specialized readers. In concentrating on a single class of neuroreceptors, the nicotinic acetylcholine receptor, it seeks to draw out general principles which apply more widely. It will therefore be welcomed not only by serious workers and students in the field of neurobiology, but also by anyone interested in the broader field of neuroscience.” Sir Aaron Klug OM FRS, Nobel laureate in Chemistry – University of Cambridge”Changeux and Edelstein have provided a concise yet highly comprehensive account of perhaps the prototypical neurotransmitter complex, the nicotinic

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